Antenatal reflex DNA screening for Down’s syndrome using total instead of free B-hCG in the Combined test
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چکیده
منابع مشابه
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Second trimester screening for Down's syndrome is widely practised throughout the world. We assessed the performance of antenatal serum screening for Down's syndrome with the quadruple test in 46193 pregnancies from 14 hospitals over 5 years. Women who screened positive (risk > or =1 in 300) were offered diagnostic amniocentesis or chorionic villus sampling. Of 88 observed Down's syndrome pregn...
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Antenatal screening for Down's syndrome.
BACKGROUND In 1968 the first antenatal diagnosis of Down's syndrome was made and screening on the basis of selecting women of advanced maternal age for amniocentesis was gradually introduced into medical practice. In 1983 it was shown that low maternal serum alpha fetoprotein (AFP) was associated with Down's syndrome. Later, raised maternal serum human chorionic gonadotrophin (hCG), and low unc...
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ژورنال
عنوان ژورنال: Journal of Medical Screening
سال: 2015
ISSN: 0969-1413,1475-5793
DOI: 10.1177/0969141315607545